Ctcf isoform
WebFeb 28, 2005 · A control pSG5 plasmid that does not express CTCF was also exploited to establish the basal focus-forming potential of cells in the absence of any exogenous CTCF isoform. Twenty-four hours post-transfection, cells were subjected to G418 selection and two weeks later the number of colonies was counted. WebHere, we explore the functions of an alternatively spliced human CTCF isoform in which exons 3 and 4 are skipped, producing a shorter isoform (CTCF-s). Functionally, we find …
Ctcf isoform
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WebNational Center for Biotechnology Information WebJun 23, 2024 · CTCF - an acronym for “CCCTC-binding factor” identified by Lobanenkov et. al. (Eur. J. Biochem. 1986) - is a highly conserved and ubiquitous protein with multivalent 11 Zn Fingers responsible for...
WebSequence & Isoform; Similar Proteins; P49711 · CTCF_HUMAN. Protein. Transcriptional repressor CTCF. Gene. CTCF. Status. UniProtKB reviewed (Swiss-Prot) Organism. … Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.
WebJul 29, 2024 · CTCF also regulates TAD formation together with the cohesin complex 17, 18, 19 in a process termed loop extrusion 20, where the ring-shaped cohesin complex attaches to chromatin strands either... WebMar 11, 2014 · CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these …
WebJun 28, 2024 · Similar to CTCF-mediated Pcdh isoform regulation (36, 37), knockdown of CTCF abrogates CTCF binding at the PUMA and p21 promoters and reduces cohesin …
WebCpG methylation, p53 and CTCF are responsible for BORIS isoform repression in somatic cells. (A) BORIS isoform expression is activated by 5-aza-dC treatment of Normal Human Dermal Fibroblasts... dana albright johnson facebookWebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. dana alarm and electricWeb5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … dana advanced manufacturing centerWebDec 20, 2024 · Moreover, CTCF interaction with the PARP-1 protein stimulates its enzymatic activity independently of DNA damage [42,45]. ... (ATM) kinase. The H1.2 isoform protects chromatin from aberrant ATM loading and activation in basal conditions. Upon DNA damage, PARP-1 covalently modifies H1.2 at the S188 residue, ... birds and bees ventura caWebJun 19, 2014 · It is closer to that of the ENSEMBL ENST00000369429 isoform than to the RefSeq isoform and ~1.6 kb from the 5' end of the RefSeq isoform (Figure 3a). Moreover, the position of the active promoter-type chromatin seen specifically in Mb ( Figure 4 b), which overlaps a constitutively unmethylated DNA region, is consistent with the use of … birds and bees store websiteWebSep 1, 2024 · The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still... dana air office in abujaWebBPTF plays an important role in regulating nucleosome occupancy at nucleosome-free regions (NFRs) at sites occupied by the multivalent factors CTCF and cohesin via direct interaction with CTCF and the cohesin subunit SA2. In addition, BPTF also interacts with c-MYC and plays an essential role in its genomic distribution and biological activity. birds and bees talk