Inthomycin
WebFormal Total Synthesis of (±)-Lycojaponicumin C - Organic Letters... Web5a Inthomycin A 4 Z, 6,8E 5b Inthomycin B 4 Z, 6E,8E 5c Inthomycin C 4E, 6 E,8E Figure 1. Some Antibacterially Active Natural Products. 692 Trends in Pharmacological Sciences, August 2016, Vol. 37, No. 8
Inthomycin
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WebMolecular Formula CHNO. Average mass 290.358 Da. Monoisotopic mass 290.163055 Da. ChemSpider ID 28285231. - Double-bond stereo. - 1 of 1 defined stereocentres. WebMay 19, 2008 · The inthomycins have been shown to be highly specific inhibitors of cellulose biosynthesis, displaying selective in vitro antimicrobial activity against Phytophtora …
WebSep 1, 2024 · Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were … Websette. Wang et al. 16] described that the inthomycin B and its two new analogues were isolated from the crude extract of Streptomyces pactum L8. Combined with the gene deletion of the rare P450 domain in the NRPS module, a formation mechanism of carboxamide moiety in inthomycins was pro-posed via an oxidative release of the …
WebSep 15, 2010 · Phthoxazolin A was first isolated from Streptomyces sp. OM-5714 in 1990 by the group of Omura [].Named inthomycin A, the same compound was isolated independently from Streptomyces strain Gö2 together with the isomers inthomycin B and inthomycin C [].Subsequently, naturally occurring hydroxylated derivatives were … WebOct 19, 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more)
WebSep 21, 2024 · The structure of lincomycin A consists of the unusual eight-carbon thiosugar core methyllincosamide (MTL) decorated with a pendent N-methylprolinyl …
WebA novel total synthesis of inthomycin C has been accomplished in 11.4% yield and 89% ee over ten linear steps from oxazole. This synthesis is the shortest and highest yielding … mary fallon artWebMoreover, the disruption/complementation experiments of itm15 also resulted in the loss and restoration of inthomycin A and B formation. Further gene cloning, expression, purification, and activity verification of itm15 revealed that Itm15 is a cyclodehydratase that catalyzes a straight-chain dehydration reaction to form an oxazole ring for the biosynthesis of … hurlburt\\u0027s hillWebThis article is cited by 16 publications. Daozhong Zhang, Zhijun Tang, Wen Liu. Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification … hurlburt\\u0027s lawWebOct 28, 2012 · The total syntheses of (+)-inthomycin A, (+)-inthomycin B and (-)-inthomycin C, the oxazole-triene antibiotics isolated from Streptomyces sp., have been … hurlburt top 3 car showWebInthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis … mary fanning 1663WebA new pathway to (+)-inthomycin C is reported that exploits an O-directed free radical hydrostannation reaction on (−)-12 and a Stille cross-coupling as key steps. Significantly, the latter process was effected on 19 where a gauche-pentane repulsive interaction could … hurlburt toms labWebStereochemical evidence is presented to demonstrate that (−)-inthomycin C has (3R)- and not (3S)-stereochemistry. Careful reappraisal of the previously published work2−5 now … mary fanning kirchhoefer