WebSep 1, 2013 · Abstract. Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics. However, serum drug levels should only be taken when there is a clear indication to guide ... WebApr 1, 2024 · nausea. numbness, tingling, or pain in the hands or feet. painful or difficult urination. pale skin. pinpoint red spots on the skin. red skin lesions, often with a purple center. red, irritated eyes. redness and swelling of the gums. slow or irregular heartbeat.
Drug Toxicity: Causes, Symptoms, Treatment - Verywell Mind
WebMay 2, 2024 · An overdose of phenytoin can be fatal. Overdose symptoms may include twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. What to avoid. Avoid drinking alcohol while you are taking phenytoin. WebJan 15, 2024 · Phenytoin displays its main signs of toxicity on the nervous and cardiovascular systems. Overdose on oral phenytoin causes mainly neurotoxicity and … full hanuman chalisa in hindi
Side effects of phenytoin - NHS
WebJan 1, 2016 · Phenytoin-induced seizures are rare, universally preceded by other signs of toxicity, and usually brief and generalized [32, 33]. Some signs of neurologic toxicity may outlast the presence of measurable drug levels by weeks, especially mild peripheral neuropathy or acute, typically reversible cerebellar ataxia [ 34 ]. WebToxicity is a constant possibility because of the manner in which phenytoin is metabolized. Small increases in dose can lead to very large increases in blood concentration, resulting in early signs of toxicity such as nystagmus, ataxia, and dysarthria. WebNov 7, 2024 · What to do if you overdose on phenytoin. If you overdose on phenytoin, call a medical professional or Poison Control at 1-800-222-1222. In case of an emergency, call 911. A phenytoin overdose can have a serious impact on the central nervous system or heart and can be fatal. Symptoms of a phenytoin overdose include confusion, vomiting, … full hard disk format software