WebApr 1, 2024 · Here, by using NG2-CreErt; Tau-mGFP mouse line to label newly-generated myelin sheaths in APP/PS1 mice, we reported that myelinogenesis and Aβ plaques in the APP/PS1 mice are brain-region dependent but not linearly correlated in the 13-month-old APP/PS1 brains after induction at the age of 6 months. Only about 15% of Aβ plaques … WebThe mGFP-positive oligodendrocytes and myelin sheaths were visualized throughout the brain; for example, cortex, corpus callosum, hippocampus and striatum (Fig. 1a). …
GFP + neurons accumulate in the aPC of postnatal Pdgfrα …
Websensory neurons. For recombination of the tau-mGFP reporter gene, 4-hydroxytamoxifen (Sigma-Aldrich) was prepared according to a pre-viouslydescribedprotocol(Indraetal.,1999)andadministered(2 g/g body weight) to timed pregnant mice at E9.5. GFP expression was ana-lyzed in E12.5 embryos by … WebTo determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen (NG2-CreERTM;... blue silk dress tapered slacks for women
Mapt Targeted Allele Detail MGI Mouse …
WebFeb 10, 2024 · At 51 days post-tamoxifen treatment, MyrfloxP/+;tau-mGFPloxP/loxP;NG2CreERT+ controls had many GFP + MBP + mature OLs with … WebJan 22, 2024 · We injected the right S1 of PdgfRα-CreER T2:Tau-mGFP mice with the AAV1/2-CAG-hM3Dq-mCherry viral vector at P5 and treated them with tamoxifen at P18 to induce recombination of the Tau-mGFP ... WebNov 16, 2016 · To study the role of these adult-born oligodendrocytes, Young et al. (2013) used Pdgfra-CreER:tau-mGFP mice in which administration of tamoxifen stimulates Cre-Lox recombination in oligodendrocyte progenitor cells that, upon differentiation, express mGFP to reveal myelin morphology. clear sewing table